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Trans-Resveratrol

CAS Number:501-36-0

Plant origin: Polygonum cusPldatum

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi.

Synonyms:
3,4’,5-Trihydroxystlbene
Trans-3,5,4'-Trihydroxystilbene
3,4',5-Stilbenetriol
Trans-Resveratrol 
(E)-5-(p-Hydroxystyryl)resorcinol (E)-5-(4-hydroxystyryl)benzene-1,3-diol

Molecular Formula: C14H12O3 Molecular Weight: 228.25
Appearance: Yellowish or white powder
Melting point: 253℃~255℃
Specification: (HPLC)≥25% ,50%, 98%
Particle size: 80 mesh
Solubility:
soluble in diethyl ether, Chloroform, Etheyl alcohol, Acetone 
Solubility in water:0.03 g/L
Solubility in DMSO:16 g/L
Solubility in ethanol:50 g/L
Storage&Shelf Life:
Store in a cool and dry area, keep sealed and keep away from direct light, high-temperature,two years when stored properly

 

Pharmacology function : Antibiotic antivirus , antitumor , resists the hepatitis , suppresses the agglutinate production with plain B2 of thrombus of blood platelet . It can prevent low density fat albumen from oxidize , have potential prevention and cure cardiovascular disease , gives protection against cancer , antivirus and immune regulating action , its function is shown as its anti-oxidant characteristic mainly.
Pharmacology function : Antibiotic antivirus , antitumor , resists the hepatitis , suppresses the agglutinate production with plain B2 of thrombus of blood platelet . It can prevent low density fat albumen from oxidize , have potential prevention and cure cardiovascular disease , gives protection against cancer , antivirus and immune regulating action , its function is shown as its anti-oxidant characteristic mainly.
Clinical practice: Used in the acute jaundice type infective hepatitis, blood silt and menorrhoea, rheumatism type arthralgia , muscle bone-ache , sand drench , blood drenching , bronchitis , damp and hot gall stone; It is too high to be used in the cholesterolemia and triglyceride; It is anti-oxidant to be used in , slowed aging.
Security : It measure security of resveratrol by the extent of damaging by leucocyte release lactic acid dehydrogenation enzyme to cell.we findthat its LD50 is weight 1000mg of each kilogram. The size of resveratrol between 5*10-7 with 10-3M cause lactic acid dehydrogenation of enzyme to release lower than 7%. Making the resveratrol has very high securities.

Results of the mouse study in terms of increased lifespan
Reference :
MacCarrone, M., et al., Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur. J. Biochem. 265, 27-34, (1999) abstract
Dobrydneva, Y., et al., trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br. J. Pharmacol. 128, 149-157, (1999) abstract
Fremont, L., Biological effects of resveratrol. Life Sci. 66, 663-673, (2000) abstract
Stewart, J.R., et.al., Resveratrol: a candidate nutritional substance for prostate cancer prevention. J. Nutr.133,2440S-2443S,(2003)abstract

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